DNA sequencing provides insight into the blueprint of living cells and individuals and is now used in many aspects of biological sciences, medicine, biotechnology and forensic sciences.
An ultrafast way to sequence DNA is to read the nucleotide letters of single DNA strands as they pass through a protein nanopore. A new study by the team of Prof. Han Remaut (VIB-VUB Center for Structural Biology) in collaboration with Oxford Nanopore Technologies presents a nanopore that is engineered to hold two constrictions. Such dual constriction nanopores are shown to be advantageous in resolving regions of DNA more difficult to read by conventional nanopores and support the generation of very high accuracy nanopore sequencing data.
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