VIB introduces an upgrade to its toolbox for structural analysis of biological molecules, leading the way for drug development. These tools help to overcome critical obstacles that limit the resolution of cryo-electron microscopy (cryo-EM) reconstructions. The latest upgrade is the use of generic MegaBodies™ as chaperones for 3D reconstructions of difficult proteins, including membrane proteins in their native state. This technology is made available via the VIB-VUB team of Professor Jan Steyaert. The Steyaert lab is recognized worldwide for pioneering applications of Nanobodies® in Structural Biology and structure-based drug discovery. Today, Nature Methods publishes a new paper on novel engineered Nanobodies®, optimized for applications in the fast growing field of cryo-EM.